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MedTerms Medical Dictionary

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Dandruff: A mild skin condition that produces white flakes that may be shed and fall from the hair.

Dandruff is due to the sebaceous glands overworking. (The sebaceous glands keep the skin properly oiled.)

Another cause of dandruff is fungus, especially one called Pitrosporum ovale. (Most people have this fungus, but people with dandruff have more.)

For dandruff, there are several tiers of treatment:

  1. First-tier dandruff treatment: A good quality upper-end shampoo (e.g., Paul Mitchell, Aveda, Redken). If several weeks using a good quality shampoo does not stop the dandruff, it can be helpful use the second-tier of dandruff treatment.
  2. Second-tier dandruff treatment: An antifungal shampoo, (e.g., (in alphabetical order) Denorex, DHS Targel, ionil-T plus, MG217, Neutrogena T/Gel, Scalpicin, Sebulex, Selsun Blue, Tegrin, Zircon).

The active ingredients approved for dandruff treatment by the U.S. Food and Drug Administration (FDA) include tar, pyrithione zinc, salicylic acid, selenium sulfide, sulfur, and ketoconazole.

Ketoconazole, once only available by prescription, was approved in 1997 by the FDA for over-the-counter (OTC) sale in the form of Nizoral A-D shampoo. This medication can be helpful for particularly difficult cases, according to some pharmacists.


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Information in the MedTerms Medical Dictionary is provided for informational purposes only and is not a substitute for professional medical advice. You should not use this information for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.